From Metrics to Meaning: Redefining Scientific Impact

The ISMPP European Meeting is a specialized annual conference focused on standards of medical publications and scientific communication. It is designed for publication planners, medical writers, and industry leaders from pharma, agencies, and journals to collaborate on best practices, such as integrating AI tools and enhancing patient involvement in research.

In the world of publications, we are often swimming in data but starving for insights. We track citations, Altmetric scores, and downloads, but how often do these numbers actually pivot our strategy?

At the ISMPP European Meeting on 28 January 2026, Mike Taylor (Head of Data Insights, Digital Science) and Radhika Bhatia (Global Head of Scientific Communication Excellence, UCB) led a provocative session called, “From Metrics to Meaning: Using Advanced Analytics to Evaluate Scientific Exchange.” Their core message was a wake-up call for the industry: If your metrics dashboard hasn’t sparked a decision in the last 12 months, it is time to rethink what you measure.

Bridging the “Post-Publication Void”

As many in our community will be aware, the “post-publication void” describes that critical disconnect between the moment a manuscript is published and the point at which it creates the desired impact. For years, the industry’s “publish and done” mentality meant research often sat dormant in journals, lacking a proactive strategy for real-world application. To bridge this gap, we must shift our focus from volume, simply counting published papers, to value: understanding how data is consumed and utilized by the target audiences.

For many teams, the publication can mark the end of a journey; however, the speakers argued that this void is actually where the true story of scientific impact begins. Traditional dashboards often prioritize outputs (what we produced) over outcomes (what changed), leaving us blind to how research is actually applied in clinical practice.

The “Pulse Check”: A Three-Tiered Framework

A live poll of the room revealed almost no attendees possessed a dashboard that had driven a major strategic pivot in the past year. To bridge this gap, Bhatia and Taylor proposed moving away from flat lists of numbers toward a three-tiered hierarchy of metrics. This framework transforms a modern analytics toolkit into a roadmap for action:

1. Dissemination (The Reach)

Reach serves as the primary metric for quantifying the breadth of a piece of content’s journey across the medical landscape, establishing the essential baseline for visibility. It is not merely about counting eyes on a page; it is about validating that the scientific narrative is penetrating the noise of a crowded digital ecosystem. By establishing this “top-of-funnel” visibility, teams can determine if their communication channels are functioning as intended or if the signal is being lost before it reaches the field.

  • Geospatial Tracking: Identifying regional “knowledge hotspots” to see where interest is concentrated.
  • Stakeholder Slicing: Categorizing reach by demographics to ensure data hits the intended audience (e.g., payers vs. specialists).

2. Engagement (The Interaction)

Engagement moves the needle from passive observation to active participation, measuring how deeply stakeholders consume and emotionally respond to the content. In an era of information overload, high engagement indicates that the data is not only seen but is also perceived as relevant and valuable enough to warrant time and scrutiny. By evaluating the quality of these interactions, organizations can discern which formats – plain language summaries, supplementary data, the full article – truly resonate with the professional needs of their audience.

  • Digital Body Language: Analyzing “dwell time” on publication extenders, such as Plain Language Summaries (PLS) and infographics.
  • Sentiment Analysis: Moving beyond “mentions” to understand if data is met with skepticism, positivity, or neutrality.

3. Impact (The Outcome)

Impact represents the “North Star” metrics that validate the clinical and commercial utility of an artifact, driving the strategic pivots necessary for long-term success. While reach and engagement measure the journey, impact measures the destination: the tangible shift in the status quo that occurs because the information was shared. This stage of measurement looks for evidence of “knowledge translation,” where scientific evidence matures into institutional change, policy shifts, and improved patient outcomes.

  • Policy & Guideline Mapping: Tracking whether research has influenced clinical guidelines, HTAs, or policy recommendations.
  • Clinical Resonance: Identifying changes in clinical behavior or patient access decisions.

For publication planners, these three pillars – Dissemination, Engagement, and Impact – do not exist in isolation; they represent a continuous feedback loop that transforms a static publication into a dynamic catalyst for change. By moving beyond traditional bibliometrics and adopting this multi-dimensional approach, planners can shift from being mere executors of a timeline to strategic partners in scientific exchange. Understanding not just who saw the data, but how they valued it and what they changed because of it, allows teams to refine their future communication strategies with surgical precision. Ultimately, this framework ensures that every publication serves a dual purpose: advancing medical science and delivering measurable value to the global healthcare community.

Redefining “Meaning” in Practice: Two Case Studies

To illustrate the practical application of the Reach-Engagement-Impact framework, the following case studies contrast two disparate publication profiles. These scenarios demonstrate why traditional metrics like citation counts can be deceptive when viewed in a vacuum. By applying a multi-tiered evaluation, publication teams can move past “vanity metrics” to uncover the true clinical resonance of their data, allowing for a strategic response that is tailored to the actual needs of the stakeholder community rather than the volume of the digital noise.

Case A: The “Low-Performing” RWE Paper

The Scenario: A real-world evidence (RWE) paper on elderly treatment adherence shows zero citations and a modest Altmetric score of 21 after 19 months.

The Re-evaluation: By pivoting to the Impact tier, the team discovered the paper was being actively utilized by regional payers and health technology assessment (HTA) committees to justify access pathways.

The Strategy: Success for RWE is rarely defined by “viral” social media chatter; it is measured by its utility to local authorities. The strategy shifted from broad, expensive promotion to targeted stakeholder support, providing deeper data subsets directly to the decision-makers who were already using the research.

Case B: The “Viral Noise” Phase 3 Paper

The Scenario: Data for a breakthrough RNA treatment goes viral, achieving an Altmetric score over 2,000 within weeks.

The Re-evaluation: Using Sentiment Analysis and Demographic Slicing, the team realized the discourse was dominated by science-skeptics questioning the platform technology rather than clinicians discussing patient outcomes.

The Strategy: Instead of celebrating the high score, Medical Affairs recognized a looming reputation risk. The strategy involved a rapid course correction, engaging patient advocacy groups and key opinion leaders (KOLs) to refocus the narrative on clinical efficacy and safety, effectively turning “noise” back into meaningful scientific engagement.

Summary of Key Strategic Insights

These cases reveal that the value of a publication is not inherent in its volume, but in its alignment with strategic objectives.

  • Context over Count: A “low” score in one tier (Reach) may hide a “high” achievement in another (Impact). Planners must define what success looks like for each specific study type, whether it is policy influence for RWE or broad awareness for Phase 3 data.
  • Quality over Quantity: High engagement levels (Case B) can actually signal a need for crisis management if the sentiment is misaligned with clinical facts.
  • Agile Realignment: Continuous monitoring across all three tiers allows Medical Affairs to pivot resources in real-time – either doubling down on a “quiet” success or correcting a “loud” misunderstanding.

Key Takeaways for Scientific Strategy

The core evolution for publication planners in 2026 is the transition from monitoring outputs to measuring outcomes. The primary takeaway from the ISMPP European session is that high-volume metrics, such as a viral Altmetric score or a large number of citations, do not always equate to successful scientific exchange, nor does a low citation count indicate failure. Instead, the value of a piece of content is defined by its alignment with specific strategic goals, whether that is influencing regional policy guidelines or correcting clinical misconceptions among patients.

To achieve this, planners must adopt a three-tiered analytical approach: quantifying Dissemination to ensure visibility, analyzing Engagement to gauge sentiment and “digital body language,” and mapping Impact to track changes in clinical behavior and policy. This framework empowers Medical Affairs to move with agility, allowing for real-time course corrections that transform “noise” into meaningful dialogue. Ultimately, success is found in the ability to prove that scientific communication has moved the needle on patient access and clinical standards, cementing the publication planner’s role as a vital strategic partner in the healthcare ecosystem.

Further Reading: Mining the Data Behind the Dialogue

Modern analytics allow publication planners to move beyond surface-level metrics to identify who is discussing their research, the underlying sentiment, and how data is being applied – from mentions in global policy documents to scrutiny within specialist clinical communities.

The post From Metrics to Meaning: Redefining Scientific Impact appeared first on Digital Science.



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๐ŸŒŸAssoc. Prof. Dr. Dongzhi Chen | Tianjin University of Finance and Economics | China๐Ÿ†


 ๐ŸŒŸ Warmest congratulations on earning the Research Excellence Award at the esteemed GSC Awards! ๐Ÿ†๐ŸŒ This outstanding achievement reflects your unwavering dedication, innovative mindset, and commitment to advancing knowledge. Your passion for research and pursuit of excellence continue to inspire colleagues, scholars, and aspiring researchers across the academic community. ๐Ÿ“š✨

Your work stands as a powerful example of how creativity and perseverance can lead to meaningful impact. ๐Ÿ”ฌ๐Ÿ’ก Through your groundbreaking ideas and rigorous efforts, you have contributed valuable insights that strengthen your field and create lasting influence. This recognition is not only a celebration of your accomplishments but also a testament to your vision and determination. ๐Ÿš€๐ŸŒŸ

As you move forward, may this well-deserved honor open doors to even greater opportunities and achievements. ๐ŸŒ ๐ŸŽ“ The future holds exciting possibilities, and your journey of innovation and discovery is far from over. Wishing you continued success, new milestones, and many more accolades in the years ahead! ๐Ÿ‘✨

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๐ŸŒŸProf. Dr. Kenjiro Nagai | Ebino centro Clinic | Japan ๐Ÿ†

 

๐ŸŒŸ Heartiest congratulations on receiving the Research Excellence Award at the prestigious GSC Awards! ๐ŸŒ๐Ÿ† This remarkable achievement is a true reflection of your unwavering dedication, intellectual brilliance, and consistent pursuit of innovation. Your research contributions not only advance knowledge in your field but also inspire fellow scholars and emerging researchers to strive for excellence. ๐Ÿ“š✨

Your journey exemplifies perseverance, passion, and a commitment to pushing the boundaries of discovery. ๐Ÿ”ฌ๐Ÿš€ Through your hard work and visionary thinking, you have created meaningful impact within the academic and professional community. This recognition stands as a testament to the countless hours of effort, critical thinking, and determination you have invested in your research endeavors. ๐ŸŒ๐Ÿ’ก

May this well-deserved honor serve as a stepping stone toward even greater accomplishments in the years ahead. ๐ŸŒ ๐ŸŽ“ As you continue to explore new frontiers and contribute groundbreaking insights, we look forward to witnessing your future milestones and global impact. Congratulations once again on this outstanding achievement! ๐Ÿ‘๐ŸŒŸ

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⚡ Geometry of the Universe: Understanding Relativity’s Solution Landscape๐Ÿ”ญ


 ๐ŸŒŒ General relativity, proposed by Albert Einstein, describes gravity not as a force but as the curvature of spacetime caused by mass and energy. ๐Ÿงฒ The “common solution space” of general relativity refers to the set of mathematical solutions to Einstein’s field equations that explain how spacetime behaves under different physical conditions. These solutions reveal how stars, planets, black holes, and even the entire universe evolve.

๐Ÿงฎ Within this solution space, famous models like the Schwarzschild solution describe non-rotating black holes, while the Friedmann–Lemaรฎtre–Robertson–Walker metric explains the expanding universe. ๐ŸŒ  Each solution represents a different geometric structure of spacetime, shaped by matter distribution and symmetry. Exploring their common features helps physicists understand gravitational waves, cosmic expansion, and singularities.

๐Ÿš€ Studying the shared mathematical structure of these solutions allows researchers to connect astrophysics, cosmology, and quantum gravity. ๐ŸŒ By mapping this common solution space, scientists aim to uncover deeper principles governing spacetime and possibly bridge general relativity with quantum mechanics—bringing us closer to a unified theory of the universe.

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⚡ Compositionality in Multitasking: Insights from Brain Circuits of Choice


 ๐Ÿง  Economic decision-making is one of the brain’s most fascinating abilities. A neural circuit framework for economic choice explores how the brain builds complex decisions from simple valuation signals. ๐Ÿ’ฐ At its core, specialized neural populations encode value, reward expectations, and risk, forming the basic “building blocks” that guide our everyday choices. These signals are integrated across distributed brain networks to shape preferences and actions.

⚙️ As tasks become more complex, the brain demonstrates compositionality — the ability to combine simple neural representations into flexible, multitasking strategies. For example, when choosing between work tasks, financial investments, or daily activities, the brain dynamically reconfigures its circuits to balance goals, context, and predicted outcomes. ⚡ This adaptability allows humans to make efficient decisions even in uncertain and rapidly changing environments.

๐Ÿ”ฌ Understanding this neural circuit framework bridges neuroscience, psychology, and behavioral economics. It helps explain how valuation processes scale from simple reward comparisons to sophisticated multitasking behaviors. ๐ŸŒ Insights from this research may inform artificial intelligence design, improve decision-making models, and provide new perspectives on disorders affecting judgment and impulse control.

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๐Ÿ”ฌ Dual-Gas Detection Using Direct Absorption & Wavelength Modulation Spectroscopy๐Ÿ“ก

๐Ÿ”ฌ Dual-gas sensing techniques are gaining significant attention in environmental and industrial monitoring. By combining Direct Absorption Spectroscopy (DAS) with Wavelength Modulation Spectroscopy (WMS), researchers can achieve both high accuracy and enhanced sensitivity. DAS provides absolute concentration measurements, while WMS improves detection limits by reducing noise and increasing signal strength. Together, they create a powerful hybrid sensing approach. ๐ŸŒซ️

⚙️ This integrated method enables simultaneous detection of two gases in real time, making it highly efficient for applications such as air quality monitoring, combustion diagnostics, and process control. The DAS component ensures reliable baseline measurements, while WMS enhances weak absorption signals, even at low gas concentrations. ๐Ÿ“ก The result is improved selectivity, stability, and precision in challenging environments.

๐ŸŒ With growing concerns about pollution and industrial emissions, dual-gas sensing systems offer a smart and scalable solution. Their compact design, fast response time, and robust performance make them suitable for field deployment. As spectroscopy technology continues to advance, this hybrid DAS-WMS approach promises greater innovation in gas analysis and environmental protection. ๐Ÿš€

 

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The Data Foundation for Natural Law Models

What if the binding constraint on the next wave of scientific AI is not compute, not talent, and not architecture but the data underneath it all? I suspect for many reading this, the instinctive response is that data is obviously important. But the gap between acknowledging its importance and actually investing in the infrastructure to make it usable is, as the past decade has taught us, rather wide.

A Genuinely New Class of AI

Over the past few years, something meaningfully different has been happening in scientific AI. Not the familiar story of language models getting larger, but something more specific and, I would argue, more consequential. AlphaFold predicted protein structures with atomic accuracy. Evo2 decoded the regulatory grammar of DNA across all domains of life. GNOME discovered 2.2 million new materials. These are not chatbots. They are not summarising papers or generating plausible-sounding text. They are learning the actual rules that govern natural phenomena. 

The Institute for Progress recently gave this class of systems a useful name: Natural Law Models (NLMs) – AI models trained on experimental data or physics-based simulations, explicitly designed to learn underlying natural phenomena. Their architectures often map onto distinct processes within the system they are studying. They are domain-specific by design. And they are producing results that general-purpose language models can’t.

When you trace the lineage of every successful NLM, you do not arrive at a clever architecture or a massive GPU cluster. You arrive at a dataset. AlphaFold was trained on the Protein Data Bank and GenBank, both products of decades of publicly funded data infrastructure. Evo2 was trained on OpenGenome2, a curated assembly of genetic sequences. GNOME and MatterGen used the Materials Project database. 

The IFP framework identifies three inputs for building NLMs: large, standardised, high-quality scientific datasets; experts with deep knowledge of both AI and the domain; and substantial compute. Of these three, data is the binding constraint in most fields– not necessarily the most expensive constraint, the binding one. The one that determines whether a model gets built at all. 

Leash Bio’s Hermes model illustrates the point well. Even a relatively simple transformer architecture can compete with state-of-the-art structure-based methods when trained on sufficient high-quality protein-ligand interaction data. Data quality and diversity matter more than model sophistication.

The FAIR Gap

This year marks 10 years since “The FAIR Guiding Principles for scientific data management and stewardship” were published. The State of Open Data report, has now analysed over 43,000 researcher responses across 10 years, reveals a persistent gap. While 85% of researchers believe open data is important for science, fewer than 30% describe their own data as truly FAIR-compliant. 

The pharmaceutical industry offers a particularly instructive case. Billions have been invested in the promise of AI-driven drug discovery. Yet what the Pistoia Alliance calls the “scientific content crisis” in pharma, critical research data remains trapped in PDFs, siloed in proprietary databases, disconnected from the experimental context that gives it meaning. It is the primary barrier to building NLMs for drug-target interaction prediction, toxicology modelling, and clinical outcome forecasting. One cannot learn the natural laws governing drug-protein interactions if half the relevant data is buried in supplementary materials that no machine can read.

Knowledge Graphs: The Connective Tissue

FAIR compliance is necessary but not sufficient. Scientific data also needs to be connected. A gene variant in ClinVar, a drug interaction in ChEMBL, a pathway annotation in Reactome, and a population frequency in gnomAD are individually useful. Linked together in a knowledge graph, they become the substrate for a class of reasoning that neither isolated databases nor language models can achieve alone. 

Knowledge graphs provide the semantic layer that transforms FAIR-compliant data into NLM training sets. They encode not just facts but relationships that a gene encodes a protein that interacts with a drug that treats a disease with a known population prevalence. This relational structure is precisely what NLMs need to learn the “natural laws” governing biological systems.

Platforms such as metaphacts’ metaphactory make this semantic layer operational. metaphactory is an enterprise knowledge graph platform that supports semantic knowledge modeling and knowledge discovery, enabling organizations to integrate heterogeneous datasets into a unified, ontology-driven graph that becomes the backbone for AI-native applications and exploration workflows. By providing a structured semantic model and an environment for discovery and collaboration, it turns disconnected life sciences data into a coherent, machine-interpretable foundation for reasoning systems. For organizations that need a high-quality scientific backbone out of the box, the Dimensions Knowledge Graph, powered by metaphactory, provides a ready-made research graph built on more than 32 billion structured statements derived from the Dimensions global research database and public data sources such as STRING and UMLS, enriched with domain ontologies. This gives teams an immediate, large-scale relational substrate that can be extended with proprietary assay data, clinical results, or real-world evidence, accelerating the transition from fragmented resources to a unified knowledge infrastructure.

The most effective AI systems for biology are not the ones with the most parameters. They are the ones with the best data infrastructure. As AI agents become central to biological research, how do we know these systems are actually working?

Phylo’s recent analysis of biology agent benchmarks reveals a challenge: failures in biology are silent. A flawed analysis can produce plausible-looking results that propagate through research pipelines for months before anyone catches the error. This is not like a chatbot hallucinating a historical date; this is a computational analysis producing a biologically plausible but incorrect result that informs real experimental decisions. Once that semantic backbone exists, AI systems must be grounded in it. 

Metis, metaphacts’ knowledge-driven AI platform, combines large language models with knowledge graphs to deliver semantically precise, contextualized insights. By explicitly grounding AI outputs in the underlying semantic layer and providing built-in quality control and explainability, it reduces hallucinations and makes it possible to trace how answers were generated. In biology, where failures are often silent and plausible-looking results can propagate through pipelines before errors are detected, this traceability is essential.

The response from the field has been the development of trace-based evaluation – scoring agents on their analytical process, not just their final answers. Phylo’s BiomniBench framework evaluates five facets – data handling, tool selection, statistical rigour, source reliability, and reasoning chain coherence. This mirrors how science itself works: peer review scrutinises methods and reasoning, not just conclusions. An agent’s analytical trace is only auditable if every data source is identified, every transformation is logged, and every inference is traceable to its evidential basis. This is, in effect, a restatement of the FAIR principles applied to AI reasoning itself. Provenance is not a nice-to-have. It is the foundation of trustworthy AI in science.

An Asymmetric Bet for Pharma

Organisations that invest in FAIR data infrastructure and knowledge graphs today are not merely improving their current research workflows– they are building the training data for tomorrow’s NLMs. Even if general-purpose LLMs eventually supersede domain-specific NLMs (the “bitter lesson” argument), the underlying datasets will still be essential as training data, fine-tuning corpora, or evaluation benchmarks.

The practical implications follow directly. Pharmaceutical companies should invest in connecting their internal experimental data to public knowledge graphs using standardised ontologies and persistent identifiers. Research funders should prioritise data infrastructure alongside experiment funding. Technology providers should build knowledge graph platforms that make FAIR compliance the default, not the exception.

AlphaFold succeeded because the Protein Data Bank existed. Decades of painstaking, publicly funded data curation created the substrate on which a model could learn the rules of protein folding. The question for every scientific field is “what is our Protein Data Bank, and are we building it?” The organisations that answer this question first will define the trajectory of AI-driven discovery for the next decade. 

The data infrastructure being built today is not about better workflows or compliance checklists. It is the foundation layer for a class of AI that is already producing genuine scientific breakthroughs.

The models will keep improving. But they can only be as good as the data they are trained on.

The post The Data Foundation for Natural Law Models appeared first on Digital Science.



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From Metrics to Meaning: Redefining Scientific Impact

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