Global Scholar Awards

2025 Research Recap: The Top 10 Publications of the Year

With thousands of papers and studies being published daily, how do you know whether your research has made any waves in the field?

How is actual “impact” or “influence” measured, and what metrics matter?

By number of citations or Altmetric score? Virality on social media? Longest title of 2025? And finally, are these measurements good, bad or simply delightful?

All of these questions (and more) are ones that data and research experts, Mike Taylor (Head of Data Insights, Digital Science), Carrie Brubaker (Medical Affairs Consultant), and Carlos Areia (Senior Data Scientist, Altmetric, part of Digital Science) began to explore as part of a Medical Affairs Professional Society (MAPS) podcast a couple of years ago. Now, they’re back and have the additional expert insight of James Dathan (Associate Director, BBU Publication, AstraZeneca) to reflect on and discuss their take on the Top 10 Most Interesting Publications of 2025 using Altmetric data. Each deliberates on why they made these lists and what made these particular publications stand out above the rest.

This year’s roundup includes curated sub-lists such as Top Altmetric Score – Clinical Trial Publication, Top All-round Highest Score, and even Top U.S. Congress Attention.

Below, we cover some selected highlights from the podcast. Did you come across any of these publications? Is yours on the list?

For the full list and insights, head over to the Top 10 Most “Interesting” Publications of 2025 on the MAPS website.

Top Altmetric Score – Clinical Trial Publication

Title: Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
By: Atonne et al
Published in: The New England Journal of Medicine, 393(1), 26-36 – May 2025
DOI: https://doi.org/10.1056/nejmoa2416394

For a detailed breakdown of the Altmetric attention, click here.

This paper contrasts the two best-known GLP-1 drugs for obesity (in the absence of diabetes), finding that injectable tirzepatide was more effective in weight loss and waist reduction (although both work well).

“Twenty years ago, this therapeutic area (drug treatments for obesity) essentially didn’t exist. The introduction of GLP-1 drugs has been the key driver, and amongst them, semaglutide and tirzepatide have had a dramatic effect on the TA and publication space… These are two big beasts being compared in this paper: given the prevalence of obesity, we shouldn’t be surprised by these numbers – in fact, we should also take a moment to reflect on how many millions of people have read about GLP1-drugs in the mainstream media, heard podcasts, read blog posts, and shared about it on social media. It’s a very real example of the power that our publications have, and how our research can change attitudes and conversations around the world.” —Mike Taylor

Title: Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
By: Musunuru et al
Published in: The New England Journal of Medicine, 392(22), 2235-2243 – May 2025
DOI: https://doi.org/10.1056/nejmoa2504747

For a detailed breakdown of the Altmetric attention, click here.

In this paper, the authors describe how a newborn child, who’d been diagnosed with a rare genetic disorder – with an estimated 50% mortality in early childhood – is treated with a custom base-editing therapy. The treatment appears to have been successful with no significant adverse effects.

Altmetric attention score graphic — A graphic visualizing the Altmetric Attention Score and media mentions for an article. The Attention Score is 4667. Media mentions are broken down as follows: 507 mentions in news outlets, 24 in blogs, 1097 by X (formerly Twitter) users, 3 on Facebook pages, 6 on Wikipedia pages, 5 by YouTube creators, 382 by Bluesky users, and 15 mentions in podcasts.

Top U.S. Congress Attention

Title: Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
By: Courneya et al
Published in: The New England Journal of Medicine, 393(1), 13-25 – June 2025
DOI: https://doi.org/10.1056/nejmoa2502760

For a detailed breakdown of the Altmetric attention, click here.

A phase 3 randomized trial found that a three-year structured exercise program after adjuvant chemotherapy for colon cancer significantly improved disease-free survival and suggested longer overall survival compared to a health-education group. At a median follow-up of eight years, the exercise group had an 80.3% five-year disease-free survival rate, compared to 73.9% in the health-education group.

“Despite not being a commercial trial, this was the most famous viral study in our congress data, particularly at the American Society of Clinical Oncology Annual Meeting (ASCO 2025), receiving exceptional positive sentiment and attention in social media, news, blogs and many other attention sources. I must disclose that I am a bit biased due to my Physio background, but I could not have this trial pass without a mention and strong congratulatory message to all involved in this brilliant and really impactful piece of work.” —Carlos Areia

Top Discussed on Podcasts

Title: Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes
By: Agarwal et al
Published in: The New England Journal of Medicine, 393(6), 533-543 – June 2025
DOI: https://doi.org/10.1056/nejmoa2410659

For a detailed breakdown of the Altmetric attention, click here.

The study investigates the effects of combining finerenone and empagliflozin in patients with CKD and type 2 diabetes. Results show that this combination therapy significantly reduces the urinary albumin-to-creatinine ratio more than either drug alone, with no unexpected adverse events reported.

Screenshot of podcast mentions – in German and English. Source: Altmetric.

“Podcasts are a new source for me, and this one is fascinating – it’s been discussed by the diabetes and renal communities, as well as amongst cardiologists. To me, seeing the enormous growth of the podcast as a means of communication and the diversity is extraordinary! This particular paper was mentioned on eight podcasts. Seeing how different therapeutic communities all engaged with this publication is fascinating – in the wild world of scientometrics, the expectation is usually that papers that cross subjects often get lower levels of activity: this paper defies those expectations. Oh, and it’s been discussed in German as well as English.” —Mike Taylor

Want to see the full list and listen to the podcast? Check out the Top 10 Most Interesting Publications of 2025 on the MAPS website.

If you’re interested in learning more about Altmetric Attention Scores or other aspects of Altmetric, contact our friendly team.

This recap was previously published on the Altmetric blog as A Year in Discovery: The Top 10 Standout Publications of 2025.

The post 2025 Research Recap: The Top 10 Publications of the Year appeared first on Digital Science.

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🧠 Intelligent Model Selection for Signal Processing Using Neural Networks📡

📡 Signal processing plays a vital role in communications, healthcare, radar, audio analysis, and many other fields. Selecting the right model for analyzing signals can significantly impact accuracy and performance. 🧠 A neural network–based model selection method leverages deep learning to automatically evaluate patterns, noise characteristics, and signal features, helping researchers choose the most suitable processing architecture.

🔍 Instead of relying solely on manual tuning or traditional statistical criteria, neural networks can learn from large datasets to compare models dynamically. ⚙️ They assess performance metrics such as prediction error, robustness, and computational efficiency. By using validation strategies and adaptive learning, these intelligent systems optimize model complexity while preventing overfitting, ensuring reliable signal interpretation.

🚀 As signal environments become more complex—especially with IoT, 5G, and biomedical applications—AI-driven model selection offers scalability and precision. 🌍 Integrating neural networks into signal processing workflows enhances automation, accelerates research, and improves real-time decision-making, paving the way for smarter and more efficient analytical systems.

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🌐 Intelligence vs Integrity: Exploring AI’s Role in Cryptographic Systems🧠

🧠 Neural cryptography explores the fascinating intersection between neural networks and traditional cryptographic systems. By leveraging machine learning models, especially artificial neural networks, researchers aim to create adaptive encryption methods that can learn secure key exchanges dynamically. 🔐 This synergy promises faster key generation, intelligent threat detection, and flexible security frameworks suited for evolving cyber environments.

⚔️ However, this relationship is not purely collaborative. Neural networks can also be used to attack cryptographic systems by identifying patterns, side-channel leaks, or weaknesses in encryption algorithms. Adversarial AI techniques may undermine security if not carefully managed. ⚡ This creates a delicate balance between using neural models to strengthen security and defending against AI-driven cryptanalysis.

🚀 As AI technologies advance, integrating neural networks into cryptographic design requires rigorous evaluation, transparency, and robustness testing. 🌍 The future of secure communication may depend on harmonizing these two powerful domains—ensuring that artificial intelligence enhances, rather than compromises, digital trust in an increasingly connected world.

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⚛️ Securing the Future: Evaluating Cryptographic Standards for Quantum Threats🔐

🔐 As quantum computing rapidly advances, traditional cryptographic standards face unprecedented challenges. Powerful quantum algorithms, such as Shor’s algorithm, threaten widely used public-key systems like RSA and ECC. ⚛️ Assessing the quantum readiness of cryptographic frameworks means evaluating whether current encryption methods can withstand attacks from future quantum machines and identifying vulnerabilities before they are exploited.

🛡️ Governments and standardization bodies are already moving toward post-quantum cryptography (PQC), promoting algorithms designed to resist quantum attacks. This transition involves rigorous testing, performance evaluation, and interoperability checks to ensure security without sacrificing efficiency. 📊 Organizations must conduct risk assessments, update compliance policies, and plan phased migrations to quantum-safe solutions.

🚀 Preparing for the quantum era is not just a technical upgrade—it’s a strategic necessity. Proactive adoption of quantum-resistant standards strengthens long-term data protection, safeguards critical infrastructure, and maintains digital trust. 🌍 By aligning cryptographic systems with emerging quantum realities, industries can confidently navigate the future of cybersecurity.

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From Metrics to Meaning: Redefining Scientific Impact

The ISMPP European Meeting is a specialized annual conference focused on standards of medical publications and scientific communication. It is designed for publication planners, medical writers, and industry leaders from pharma, agencies, and journals to collaborate on best practices, such as integrating AI tools and enhancing patient involvement in research.

In the world of publications, we are often swimming in data but starving for insights. We track citations, Altmetric scores, and downloads, but how often do these numbers actually pivot our strategy?

At the ISMPP European Meeting on 28 January 2026, Mike Taylor (Head of Data Insights, Digital Science) and Radhika Bhatia (Global Head of Scientific Communication Excellence, UCB) led a provocative session called, “From Metrics to Meaning: Using Advanced Analytics to Evaluate Scientific Exchange.” Their core message was a wake-up call for the industry: If your metrics dashboard hasn’t sparked a decision in the last 12 months, it is time to rethink what you measure.

Bridging the “Post-Publication Void”

As many in our community will be aware, the “post-publication void” describes that critical disconnect between the moment a manuscript is published and the point at which it creates the desired impact. For years, the industry’s “publish and done” mentality meant research often sat dormant in journals, lacking a proactive strategy for real-world application. To bridge this gap, we must shift our focus from volume, simply counting published papers, to value: understanding how data is consumed and utilized by the target audiences.

For many teams, the publication can mark the end of a journey; however, the speakers argued that this void is actually where the true story of scientific impact begins. Traditional dashboards often prioritize outputs (what we produced) over outcomes (what changed), leaving us blind to how research is actually applied in clinical practice.

The “Pulse Check”: A Three-Tiered Framework

A live poll of the room revealed almost no attendees possessed a dashboard that had driven a major strategic pivot in the past year. To bridge this gap, Bhatia and Taylor proposed moving away from flat lists of numbers toward a three-tiered hierarchy of metrics. This framework transforms a modern analytics toolkit into a roadmap for action:

1. Dissemination (The Reach)

Reach serves as the primary metric for quantifying the breadth of a piece of content’s journey across the medical landscape, establishing the essential baseline for visibility. It is not merely about counting eyes on a page; it is about validating that the scientific narrative is penetrating the noise of a crowded digital ecosystem. By establishing this “top-of-funnel” visibility, teams can determine if their communication channels are functioning as intended or if the signal is being lost before it reaches the field.

Geospatial Tracking: Identifying regional “knowledge hotspots” to see where interest is concentrated.
Stakeholder Slicing: Categorizing reach by demographics to ensure data hits the intended audience (e.g., payers vs. specialists).

2. Engagement (The Interaction)

Engagement moves the needle from passive observation to active participation, measuring how deeply stakeholders consume and emotionally respond to the content. In an era of information overload, high engagement indicates that the data is not only seen but is also perceived as relevant and valuable enough to warrant time and scrutiny. By evaluating the quality of these interactions, organizations can discern which formats – plain language summaries, supplementary data, the full article – truly resonate with the professional needs of their audience.

Digital Body Language: Analyzing “dwell time” on publication extenders, such as Plain Language Summaries (PLS) and infographics.
Sentiment Analysis: Moving beyond “mentions” to understand if data is met with skepticism, positivity, or neutrality.

3. Impact (The Outcome)

Impact represents the “North Star” metrics that validate the clinical and commercial utility of an artifact, driving the strategic pivots necessary for long-term success. While reach and engagement measure the journey, impact measures the destination: the tangible shift in the status quo that occurs because the information was shared. This stage of measurement looks for evidence of “knowledge translation,” where scientific evidence matures into institutional change, policy shifts, and improved patient outcomes.

Policy & Guideline Mapping: Tracking whether research has influenced clinical guidelines, HTAs, or policy recommendations.
Clinical Resonance: Identifying changes in clinical behavior or patient access decisions.

For publication planners, these three pillars – Dissemination, Engagement, and Impact – do not exist in isolation; they represent a continuous feedback loop that transforms a static publication into a dynamic catalyst for change. By moving beyond traditional bibliometrics and adopting this multi-dimensional approach, planners can shift from being mere executors of a timeline to strategic partners in scientific exchange. Understanding not just who saw the data, but how they valued it and what they changed because of it, allows teams to refine their future communication strategies with surgical precision. Ultimately, this framework ensures that every publication serves a dual purpose: advancing medical science and delivering measurable value to the global healthcare community.

Redefining “Meaning” in Practice: Two Case Studies

To illustrate the practical application of the Reach-Engagement-Impact framework, the following case studies contrast two disparate publication profiles. These scenarios demonstrate why traditional metrics like citation counts can be deceptive when viewed in a vacuum. By applying a multi-tiered evaluation, publication teams can move past “vanity metrics” to uncover the true clinical resonance of their data, allowing for a strategic response that is tailored to the actual needs of the stakeholder community rather than the volume of the digital noise.

Case A: The “Low-Performing” RWE Paper

The Scenario: A real-world evidence (RWE) paper on elderly treatment adherence shows zero citations and a modest Altmetric score of 21 after 19 months.

The Re-evaluation: By pivoting to the Impact tier, the team discovered the paper was being actively utilized by regional payers and health technology assessment (HTA) committees to justify access pathways.

The Strategy: Success for RWE is rarely defined by “viral” social media chatter; it is measured by its utility to local authorities. The strategy shifted from broad, expensive promotion to targeted stakeholder support, providing deeper data subsets directly to the decision-makers who were already using the research.

Case B: The “Viral Noise” Phase 3 Paper

The Scenario: Data for a breakthrough RNA treatment goes viral, achieving an Altmetric score over 2,000 within weeks.

The Re-evaluation: Using Sentiment Analysis and Demographic Slicing, the team realized the discourse was dominated by science-skeptics questioning the platform technology rather than clinicians discussing patient outcomes.

The Strategy: Instead of celebrating the high score, Medical Affairs recognized a looming reputation risk. The strategy involved a rapid course correction, engaging patient advocacy groups and key opinion leaders (KOLs) to refocus the narrative on clinical efficacy and safety, effectively turning “noise” back into meaningful scientific engagement.

Summary of Key Strategic Insights

These cases reveal that the value of a publication is not inherent in its volume, but in its alignment with strategic objectives.

Context over Count: A “low” score in one tier (Reach) may hide a “high” achievement in another (Impact). Planners must define what success looks like for each specific study type, whether it is policy influence for RWE or broad awareness for Phase 3 data.
Quality over Quantity: High engagement levels (Case B) can actually signal a need for crisis management if the sentiment is misaligned with clinical facts.
Agile Realignment: Continuous monitoring across all three tiers allows Medical Affairs to pivot resources in real-time – either doubling down on a “quiet” success or correcting a “loud” misunderstanding.

Key Takeaways for Scientific Strategy

The core evolution for publication planners in 2026 is the transition from monitoring outputs to measuring outcomes. The primary takeaway from the ISMPP European session is that high-volume metrics, such as a viral Altmetric score or a large number of citations, do not always equate to successful scientific exchange, nor does a low citation count indicate failure. Instead, the value of a piece of content is defined by its alignment with specific strategic goals, whether that is influencing regional policy guidelines or correcting clinical misconceptions among patients.

To achieve this, planners must adopt a three-tiered analytical approach: quantifying Dissemination to ensure visibility, analyzing Engagement to gauge sentiment and “digital body language,” and mapping Impact to track changes in clinical behavior and policy. This framework empowers Medical Affairs to move with agility, allowing for real-time course corrections that transform “noise” into meaningful dialogue. Ultimately, success is found in the ability to prove that scientific communication has moved the needle on patient access and clinical standards, cementing the publication planner’s role as a vital strategic partner in the healthcare ecosystem.

🌟Assoc. Prof. Dr. Dongzhi Chen | Tianjin University of Finance and Economics | China🏆

🌟 Warmest congratulations on earning the Research Excellence Award at the esteemed GSC Awards! 🏆🌍 This outstanding achievement reflects your unwavering dedication, innovative mindset, and commitment to advancing knowledge. Your passion for research and pursuit of excellence continue to inspire colleagues, scholars, and aspiring researchers across the academic community. 📚✨

Your work stands as a powerful example of how creativity and perseverance can lead to meaningful impact. 🔬💡 Through your groundbreaking ideas and rigorous efforts, you have contributed valuable insights that strengthen your field and create lasting influence. This recognition is not only a celebration of your accomplishments but also a testament to your vision and determination. 🚀🌟

As you move forward, may this well-deserved honor open doors to even greater opportunities and achievements. 🌠🎓 The future holds exciting possibilities, and your journey of innovation and discovery is far from over. Wishing you continued success, new milestones, and many more accolades in the years ahead! 👏✨

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🌟Prof. Dr. Kenjiro Nagai | Ebino centro Clinic | Japan 🏆

🌟 Heartiest congratulations on receiving the Research Excellence Award at the prestigious GSC Awards! 🌐🏆 This remarkable achievement is a true reflection of your unwavering dedication, intellectual brilliance, and consistent pursuit of innovation. Your research contributions not only advance knowledge in your field but also inspire fellow scholars and emerging researchers to strive for excellence. 📚✨

Your journey exemplifies perseverance, passion, and a commitment to pushing the boundaries of discovery. 🔬🚀 Through your hard work and visionary thinking, you have created meaningful impact within the academic and professional community. This recognition stands as a testament to the countless hours of effort, critical thinking, and determination you have invested in your research endeavors. 🌍💡

May this well-deserved honor serve as a stepping stone toward even greater accomplishments in the years ahead. 🌠🎓 As you continue to explore new frontiers and contribute groundbreaking insights, we look forward to witnessing your future milestones and global impact. Congratulations once again on this outstanding achievement! 👏🌟

Global Scholar Awards

2025 Research Recap: The Top 10 Publications of the Year