Tissue Self-Organisation: Five Basic Rules Discovered

 Researchers from Helen F. Graham Cancer Center & Research Institute and University of Delaware found that the architecture of bodily tissues (for example colon lining) can be explained by just five basic rules that govern how cells die, divide, move and organise themselves. This long-term collaboration between cancer biologists and mathematicians suggests we may soon have a “blueprint” for how tissues maintain structure despite constant turnover.

A “Search Engine for DNA” Opens Biology’s Big Data

A new platform called MetaGraph has been developed to compress vast biological sequence archives into a searchable engine — essentially a “Google for DNA”. This addresses a growing bottleneck: while genomics and molecular-biology generate massive data, making sense of it has lagged. 

2025 Nobel Prize in Medicine: Immune “Security Guard” Cells

The 2025 Nobel Prize in Physiology or Medicine has been awarded to Shimon Sakaguchi, Mary E. Brunkow and Fred Ramsdell for their discovery of specialized immune cells that act as security guards — preventing the immune system from turning against the body (auto-immunity) and regulating immune responses. 

Internal Fat Biology Linked to Heart Failure

A new hypothesis shows that changes in the biology of internal fat (not just surface fat) may be a key factor in the development of a form of heart failure called heart failure with preserved ejection fraction (HFpEF). The study suggests that these fat tissues change their function, not just their volume, leading to cardiac problems. 

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