🧫 Mechanosensing–Metabolism Coupling via Catalytic Ligands 🔄


Catalysis-mediated dynamic ligand presentation is emerging as a powerful strategy to understand how stem cells interpret their microenvironment 🔬✨. Unlike static biomaterials, dynamically presented ligands can change in response to catalytic reactions ⚙️, allowing cells to continuously sense and adapt to mechanical signals such as stiffness, tension, and force 📐🧲. This dynamic interaction plays a key role in how stem cells attach, spread, and organize their cytoskeleton 🧬.

Mechanosensing does not act alone—it is tightly linked to cellular metabolism 🔄🔥. When stem cells experience mechanical cues, these signals are transmitted through integrins and cytoskeletal networks, ultimately influencing metabolic pathways like glycolysis and mitochondrial activity ⚡🫁. Catalysis-mediated ligand changes fine-tune this process, ensuring that energy production matches mechanical demand, which is crucial for maintaining stemness or triggering differentiation 🌱.

By coupling mechanosensing with metabolism, dynamic ligand presentation offers exciting opportunities for tissue engineering and regenerative medicine 🏥🚀. Designing smart biomaterials that actively communicate with stem cells can improve cell fate control, enhance regeneration, and mimic natural extracellular matrices more accurately 🧫🌍. This approach opens new doors for creating adaptive cell environments that respond intelligently to biological needs 💡🧠.

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