🧪🔬 Recent Trends in Sampling & Sorbent-Based Sample Preparation for Bioanalytical Applications 💉

Bioanalytical science is evolving rapidly, and one of the most promising areas is the transformation of sampling and sorbent-based sample preparation techniques 🧪⚡. Traditional workflows often required large sample volumes and lengthy steps, but today’s innovations focus on miniaturization, precision, and efficiency. Micro-sampling tools such as dried blood spots (DBS), volumetric absorptive microsampling (VAMS), and microfluidic devices allow researchers to collect tiny biological samples 💉 while maintaining high analytical quality. These tools make sampling less invasive, faster, and more suitable for point-of-care and field studies 🌍.

Sorbent-based approaches have undergone a major upgrade, thanks to the introduction of advanced materials like nanomaterials, magnetic particles, metal–organic frameworks (MOFs), and molecularly imprinted polymers (MIPs) 🧲🧬. These sorbents offer higher surface area, improved selectivity, and better binding efficiency. Techniques such as solid-phase microextraction (SPME), dispersive solid-phase extraction (dSPE), and magnetic solid-phase extraction (MSPE) are now widely adopted for their speed and solvent-saving benefits 🌱. With automation-friendly formats, labs can now achieve higher throughput and more reproducible results than ever before.

Looking ahead, the field is moving toward greener, smarter, and more integrated sample preparation workflows 🌿🤖. Sustainable sorbents, reusable extraction devices, and solventless microextraction are gaining popularity as researchers aim to reduce environmental footprints. Additionally, AI-guided optimization, lab-on-a-chip systems, and real-time monitoring tools are shaping the future of bioanalysis 🔍✨. Together, these innovations ensure that sampling and preparation become not just faster and cleaner, but also more accessible and eco-friendly—empowering the next generation of biomedical, pharmaceutical, and clinical research.

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